The toothpaste
Question

Sensitive teeth over 60: recession, root surfaces and medication dry mouth.

Past sixty, a tooth that has turned sensitive is most often an exposed root, and what helps starts with a dental check and a sensitivity toothpaste that keeps full-strength fluoride, because the gum recession that uncovers the root is also the main cause of decay on it1. The options with the strongest trial evidence for an older mouth come from a dental professional rather than a shop: a prescription 5,000 ppm fluoride toothpaste against root decay2, and a silver diamine fluoride solution painted onto a sensitive root in the surgery3. S3 Sensitivity Science™ was formulated for sensitivity where gum recession has left dentine tubules open and the nerve reactive at the same time.

What was checked27 peer-reviewed studies, product information as published by S3, and guidance from the NHS, NICE, the Oral Health Foundation and the UK government's oral health toolkit for dental teams

Key points
  • In a population survey that examined adults at home, people over sixty were less likely to have sensitive teeth than people in their late thirties and forties, so a tooth that starts to hurt at seventy is worth a dental examination before a new tube4.
  • For decay on an exposed root, randomised trials in older adults favour a prescription 5,000 ppm fluoride toothpaste over the 1,450 ppm strength sold in shops, and a systematic review of the root-decay trials says that conclusion rests on only a few of them25.
  • S3 carries 1450 ppm fluoride, the adult strength sold over the counter; the 5,000 ppm toothpaste used in the root-decay trials is a prescription product, and S3 is not one.
  • In a double-blind trial of 148 older adults, silver diamine fluoride painted on by a clinician reduced cold-air sensitivity on exposed roots more than a potassium nitrate solution applied the same way, and UK guidance notes that the silver solution blackens teeth36.
  • Medicines are the main cause of a dry mouth in older people, and a dry mouth makes decay more likely, so take the list of medicines to a pharmacist or GP and stop none of them without medical advice78.

Do teeth get more sensitive after 60?

Not in most of the surveys that examined people's teeth, and that is the reason a new sensitivity at this age deserves a closer look. In a population sample of 1,023 adults aged 35 and over in Porto Alegre, Brazil, examined at home with an air blast and a probe, people aged 60 and over were less likely to have dentine hypersensitivity than those aged 35 to 49, with an odds ratio of 0.474. An industry-funded examination of 3,551 adults in seven European countries found sensitivity climbing through young adulthood and declining after about 38 to 479.

Not every dataset agrees. A multicentre survey of 2,640 urban adults in two Chinese cities found the largest number of affected people in the 50 to 59 group10, and a review in the British Dental Journal argues that as people keep their own teeth for longer, wear and sensitivity could become more common in an ageing population11. The Oral Health Foundation's page for the public says sensitivity becomes more common as we get older because gums recede12; the surveys that examined teeth mostly do not bear that out. The page on prevalence and the age curve lays those datasets side by side, and the page on sensitive teeth in your forties and fifties covers the decades before this one.

Asking people gives a different number from examining them. When every 75-year-old in two Swedish counties was sent a postal questionnaire, 20.3% of the 3,735 who answered in 2007 and 21.6% of the 5,091 who answered in 2017 reported at least some trouble with sensitive teeth, women more often than men13. That is about one in five, self-reported, with nobody examined and no younger group to set it against.

The practical consequence comes before any toothpaste. The NHS counts a sharp pain in a tooth with hot, cold or sweet food and drink among the symptoms of a hole caused by decay14, and its toothache page names decay, a cracked or damaged tooth and a loose or broken filling among the causes of tooth pain15. At seventy, those need ruling out before a tooth that has started to hurt is treated as ordinary sensitivity. The Journal's article on tooth sensitivity after a filling covers the pain that follows dental work.

That rule includes S3: it was made for sensitivity from recession, where exposed tubules and a reactive nerve both play a part, and a new pain at this age should reach a dentist before it reaches any new tube.

Why is it usually the root, and why does that matter for decay?

Because gum recession uncovers root dentine with no enamel over it, and a review of age-related changes in teeth names recession as the main cause both of dentine hypersensitivity and of root decay1. The same bare surface can hurt and can decay, and the two call for different help.

Age changes the dentine as well. Inside the tooth, according to that review, new layers of dentine are laid down and the channels running through it get narrower, a change known as dentine sclerosis1. In a laboratory comparison of 24 extracted teeth, those from donors aged 60 or over had more calcium in the dentine lining their tubules than teeth from donors aged 25 or under, which the authors connect to tubules filling with mineral over time16. That is a finding about structure on a laboratory bench, not about how a tooth in a living mouth feels16.

Recession on its own decides less than it seems. In the Porto Alegre sample only about one tooth in ten with gum recession was sensitive4, and among 349 young adults examined in the UK, recession was found in every mouth while the authors recorded many receded teeth that were not sensitive at all17. The page on gum recession and sensitivity covers why the gum moves and what can be done about it.

Decay is the other reason the root matters. In a 2013 review of fluoride research, ordinary fluoride toothpaste had a fair effect on sensitivity mainly when a second agent such as a potassium salt was also at work in the tubules, while the stronger fluorides the review recommends, a 5,000 ppm toothpaste and rinses, gels or varnishes applied three to four times a year, were recommended for preventing root decay rather than for relief18.

The routine that protects a bare root is plain. The NHS advice is fluoride toothpaste at least twice a day, spat out after brushing and not rinsed off with water14, and a randomised trial of 120 adults found that rinsing with water after brushing changed how much fluoride stayed in the saliva19. The Journal's explainer on what dentine tubules are shows the channels an exposed root leaves open.

Could your medicines be making it worse?

They can, by drying the mouth: the NHS lists medicines among the main causes of a dry mouth and says tooth decay is more likely when the mouth is dry8. Less saliva leaves a bare root more open to decay, and decay on a root is one of the things that makes a tooth sensitive.

Dry mouth is common at this age, and medicines are the main reason. A 2021 review written for pharmacists puts dry mouth at 20% to 30% of people over 65, higher than in any other age group, and names polypharmacy, taking five or more medicines, as the major risk factor, with dryness more likely the more medicines a person takes7. In the Swedish postal surveys of 75-year-olds, 37.5% in 2007 and 34.8% in 2017 said their mouth was dry during the day13.

The same review singles out antidepressants, anticholinergics, opioids and bronchodilators as the classes with sound evidence of drying the mouth7, and the Oral Health Foundation names medicines for high blood pressure, depression and anxiety, and says saliva production can slow as part of normal ageing20. A 2018 review of medication-induced dry mouth in older patients describes the effects reaching swallowing, nutrition, quality of life and decay21.

The NHS is clear on one point: do not stop taking a prescribed medicine without medical advice, even if you suspect it is behind the dryness, and if you still have your own teeth, do not use acidic artificial saliva products8. Its route is a pharmacist for dry-mouth products and a GP if you think a prescribed medicine is the cause8. Take the whole list, including anything bought without a prescription. The Oral Health Foundation says there may be an alternative with fewer side effects20, and the 2018 review lists moving to a less drying medicine, or lowering a dose where that is possible, among the options open to prescribers21. Whether a medicines review actually eases a dry mouth has not yet been tested in a randomised trial, the 2021 review notes7.

Sugar-free gum appears in both the NHS and the Oral Health Foundation advice for a dry mouth820. The record of xylitol against decay is mixed. In a placebo-controlled trial at three US dental schools, 691 adults at raised risk of decay took xylitol or placebo lozenges for 33 months, and the xylitol did not significantly reduce new decay22. A later analysis of the same randomised trial, broken down by tooth surface, found 40% fewer root lesions with xylitol, a secondary result rather than the question the trial was built to answer23. Both concern lozenges, and neither tells you anything about xylitol in a toothpaste. The page on a daily routine for a dry mouth in perimenopause goes through dry-mouth products and enamel in more detail.

Where does a paste like S3 fit, and what is it not a substitute for?

At home, as the everyday toothpaste for sensitivity on an exposed root, and never in place of the decay check, the prescription fluoride or the treatments a dentist applies. S3 is designed as a complete daily toothpaste.

Its ingredient list puts 5% potassium nitrate, for the nerve, beside a 10% nano-hydroxyapatite solution and 5% biomimetic hydroxyapatite, and keeps fluoride at the full adult level. The 10% and 5% describe how much of each hydroxyapatite ingredient goes in as supplied, so the hydroxyapatite actually present is a smaller share of the tube, and S3 publishes both figures. On an exposed root the three are meant to split the work, with potassium for the nerve, the nano form down in the tubule and the biomimetic form over the surface, and none of them can stand in for another. Like any paste built on these actives, S3 is judged at two to four weeks, because potassium builds up around the nerve and mineral is laid down brush by brush.

What the pooled trials say about those actives was learned in adults of every age, and it does not flatter them. A 2026 network meta-analysis of 93 randomised trials rated the two-week effect of potassium toothpastes as small, from a single trial, with low confidence, and gave its one high-confidence rating to stannous fluoride, which S3 does not contain24. Pooling six trials of 5% potassium nitrate pastes, the 2006 Cochrane review saw better air-blast and probe scores after six to eight weeks but no significant change in how sensitive people themselves said their teeth were25. An earlier network meta-analysis, of 125 randomised trials and 12,541 patients, found potassium pastes reduced sensitivity to a probe more than fluoride-only toothpaste, with moderate certainty26.

Nothing found for this page tested a sensitivity toothpaste in older adults alone. A PubMed search run on the tenth of September 2026 for randomised trials of desensitising toothpastes that mention older people returned 97 records, and the one older-adult trial of a sensitivity treatment among them tested solutions a clinician painted on, not a paste3. None of the evidence for the actives in S3 is specific to people over sixty.

For decay on a root, the trials in older adults favour a prescription 5,000 ppm toothpaste, while S3's fluoride, 1450 ppm as sodium monofluorophosphate, sits at the everyday adult level that those trials used as the comparison2. No claim is made here that it eases a dry mouth either. The page on whether sensitivity can be managed for good covers what years of daily care can and cannot do.

What can a dentist offer for a sensitive root?

A diagnosis first, then treatments no shop sells: a solution painted onto the sensitive root in the chair, varnish for a root at risk, and a prescription toothpaste if decay has started or the risk is high. The Journal's guide to why teeth become sensitive lists the causes a dentist will be checking for.

The table sets the options side by side, with S3 as one example of the daily-toothpaste row, listed by its declared actives and its 1450 ppm fluoride.

OptionWhat it is forWho supplies itBest evidence in older adultsTrade-offs
A daily sensitivity toothpaste with 1,450 ppm fluoride (S3 is one: 5% potassium nitrate, 10% nano-hydroxyapatite solution, 5% biomimetic hydroxyapatite, 1450 ppm fluoride as sodium monofluorophosphate)Sensitivity, with everyday decay preventionYou, from a shop, a pharmacy or a brand's websiteNo trial recruited only older adults (PubMed search, 97 records, 10 September 2026); in mixed-age adults, potassium pastes showed a small two-week effect at low confidence in a 2026 network meta-analysis24Judged over weeks; not prescription strength against root decay
Prescription 5,000 ppm fluoride toothpasteRoot decay, not sensitivityA dentist, on prescription, for high decay risk from age 166Double-blind RCT, 345 older adults, two years, no funding declared in the record2; RCT in 176 care home residents, eight months27; systematic review: a few trials5; UK guidance: low certainty6A prescription; reviewed at check-ups and not normally long term
Silver diamine fluoride, painted on in the surgeryRoot sensitivity (its UK licence); arresting root decay in reviewsA dentistDouble-blind RCT, 148 older adults, eight weeks, no conflicts declared: median 60% less cold-air sensitivity against 50% for a potassium nitrate solution, no placebo arm3; systematic review of seven trials in adults 60 and over: 42% of root lesions arrested at 24 months28Blackens the treated surface6
Fluoride varnishPreventing root decayThe dental team, at visitsSystematic review of trials in adults 60 and over: root caries-prevented fraction 64%28; UK guidance: consider for frail older people with natural teeth6Repeat visits; no staining
Xylitol gum or lozengesDry-mouth comfort (gum); decay (lozenges)YouPlacebo-controlled lozenge RCT in adults at raised decay risk, 33 months: no significant reduction in decay22; a secondary analysis of the same trial found 40% fewer root lesions23Not a toothpaste finding; the root result is secondary
Gum surgery to cover the rootSensitivity from recessionA periodontistMeta-analysis of 13 RCTs in adults of all ages: sensitivity suppressed in 70.8% of cases; no trial against a toothpaste29An operation; not every recession is suitable

A treatment painted onto the root

In the one randomised trial in older adults found for this page, run in Hong Kong with 148 participants and no declared conflicts of interest, a 38% silver diamine fluoride solution painted onto sensitive roots by a clinician at three visits over eight weeks reduced cold-air sensitivity by a median 60%, against 50% for a 5% potassium nitrate solution applied the same way3. Potassium nitrate is the nerve-calming active in S3, so on this one trial the active S3 relies on came second, used as a painted solution rather than in a toothpaste3.

Both groups improved and the trial had no placebo arm, so it shows which of two active treatments did more, not what either does against nothing3. In the UK, the licence for silver diamine fluoride covers dentine hypersensitivity rather than decay, and the government's prevention toolkit for dental teams warns that it blackens teeth6. Where the stain would show is a fair question to ask before agreeing.

A 2013 network meta-analysis of 40 studies of treatments applied in the surgery found most did better than placebo and could not rank them against one another30. Sensitivity after a deep clean of the roots has its own small evidence base: in a 2020 systematic review of nine randomised trials, desensitising agents reduced pain to water and air stimuli with low to very low certainty, while control groups did better on a probe test31.

Fluoride for a root at risk of decay

The same silver solution has a record against root decay in this age group. A 2022 systematic review of seven trials in adults aged 60 and over found that fluoride varnish and fluoride gel prevented root decay, and that silver diamine fluoride both prevented it and, in the meta-analysis, arrested 42% of root lesions at 24 months28. A 2020 network meta-analysis of nine trials with 4,030 participants ranked an annual application of 38% silver diamine fluoride, given with oral health advice, as the professional option most likely to prevent new root decay32. UK guidance asks dental teams to consider fluoride varnish for adults at higher risk, particularly frail older people who have kept their own teeth, and points out that varnish carries no aesthetic drawback6.

A prescription toothpaste when the root is decaying

For decay that has already started on a root, the prescription toothpaste has the most direct trial evidence in older adults2. In a two-year double-blind trial of 345 older adults living independently, each with at least one decayed root, the share of teeth with active root decay rose from 24.32% to 40.52% on a 1,450 ppm toothpaste and fell from 29.74% to 3.72% on a 5,000 ppm toothpaste2. In six Copenhagen care homes, where staff brushed the teeth of 176 residents twice a day for eight months, residents on the 5,000 ppm paste finished with an average of 1.05 active root lesions against 2.55 on 1,450 ppm, and more of their lesions had turned into arrested decay27. A six-month trial of 130 adults with root decay in Germany and Switzerland, funded by the manufacturer that supplied both pastes and employs two of the authors, found root lesions hardened more on a 5,000 ppm paste than on a 1,350 ppm paste, significantly so at six months but not at three33.

The reviews agree on the direction and are candid about its limits. A 2019 systematic review prepared for European cariology bodies concluded that 5,000 ppm toothpaste, and chlorhexidine varnish or silver diamine fluoride applied by a professional, seemed more effective at arresting root decay than ordinary fluoride toothpaste or placebo, and that the conclusion rests on only a few randomised trials5. The government toolkit for UK dental teams grades the evidence for these root-decay treatments as low certainty, lists a dry mouth and existing root decay among the reasons to prescribe the 5,000 ppm paste to people aged 16 and over at high risk, and says it is not normally for the long term6. The page on what "strong" means for a sensitivity toothpaste explains why prescription strength is about decay, not sensitivity.

Surgery for the recession itself

Covering an exposed root with gum is a periodontist's option where the recession suits it: across 13 randomised trials pooled in a 2022 meta-analysis, sensitivity was suppressed after surgery in 70.8% of cases, and every one of those trials compared one operation with another rather than with a toothpaste29.

It helps to arrive with questions:

If someone helps with brushing, what should that include?

Brushing natural teeth at least twice a day with fluoride toothpaste, daily use of anything a dentist has prescribed, and the person's own choice of products wherever possible, which is what NICE asks care home managers to make sure staff provide34.

NICE's recommendations on daily mouth care in care homes follow the government's oral health toolkit and spell the routine out: brushing natural teeth at least twice a day with fluoride toothpaste; the resident's choice of toothbrush, manual or powered; daily use of mouth care products prescribed by dental clinicians, which may include a high fluoride toothpaste or a prescribed mouth rinse; and daily use of any over-the-counter toothpaste or rinse the resident prefers, where possible, with gum containing xylitol suggested for anyone who already chews sugar-free gum34. The same guideline asks for a resident's mouth care needs to be assessed when they move in and written into their personal care plan, and for staff to know whom to ask about getting prescribed mouth care products34.

The care home trial above is the nearest evidence to this situation: when staff did the brushing, the prescription-strength paste controlled root decay better than the ordinary one over eight months27. At home the same principles hold for a partner or an adult child who helps: fluoride toothpaste twice a day, spat out rather than rinsed away14, any prescribed paste used as the dentist directs, and new pain reported to the dentist rather than covered with a new tube.

Frequently asked questions

Is S3 a substitute for a prescription fluoride toothpaste?

No. The two do different jobs at different strengths. A 5,000 ppm prescription toothpaste is for people aged 16 and over whom a dentist judges to be at high risk of decay, with root decay and a dry mouth among the reasons, and it is reviewed at check-ups rather than used long term as a matter of course6. S3 is a sensitivity toothpaste with 1450 ppm fluoride as sodium monofluorophosphate, the ordinary adult strength, alongside potassium nitrate and two forms of hydroxyapatite. If your dentist does prescribe it, ask them how a sensitivity paste fits around it.

Why are my teeth sensitive at the gumline?

Usually because the gum has moved back and uncovered root dentine, and a review of how teeth change with age names recession as the main cause of both sensitivity and root decay1. Most receded teeth do not hurt, though: in a Brazilian population sample only about one tooth in ten with recession was sensitive4. See a dentist sooner if the pain is severe, has gone on for more than a few weeks, sits in one tooth or arrived suddenly; the Oral Health Foundation lists those as possible signs of decay, a cracked tooth, gum trouble or infection12.

Can my medicines cause sensitive teeth?

They can play a part through a dry mouth. The NHS lists medicines among the main causes of a dry mouth and says decay is more likely when the mouth is dry8, and it counts a sharp pain with hot, cold or sweet things among the symptoms of decay14. Take the full list to a pharmacist or GP, and do not stop any prescribed medicine without advice8.

Is the black staining from silver diamine fluoride permanent?

The sources behind this page do not say how long it lasts. UK guidance for dental teams says the solution blackens teeth6, and the Hong Kong trial on sensitive roots reported pain scores rather than how the teeth looked afterwards3. Ask the dentist to show you which surfaces would be treated, and how visible they are, before you agree.

Should a carer use a sensitivity toothpaste for someone in a care home?

If the resident already prefers one, NICE's care home guideline asks staff to keep providing preferred over-the-counter toothpastes where possible, and any high fluoride toothpaste a dentist has prescribed is used every day as prescribed34. Which paste does which job is for the resident's dentist to set out in the care plan, not for staff to decide from the shelf.

Where S3 sits

For an exposed root that is sensitive, the home half is a daily paste that calms the nerve and works on open dentine, with fluoride kept at full adult strength, 1450 ppm. The other half happens in the surgery, where decay is ruled out, prescription fluoride is weighed if the risk is high and a painted-on treatment is considered if the pain persists; that half holds the strongest evidence for an older mouth, and S3 was formulated for recession-related sensitivity at home, not to replace it. Unlike fluoride-free hydroxyapatite pastes, S3 does not ask anyone to give up decay protection.

S3 Sensitivity Science™ pairs potassium nitrate with two hydroxyapatites and adult-strength fluoride in one daily paste.

See the toothpaste

S3 Sensitivity Science™ pairs 5% potassium nitrate for the nerve with two forms of hydroxyapatite, a 10% nano-hydroxyapatite solution and 5% biomimetic hydroxyapatite, and keeps 1450 ppm fluoride, all in one daily toothpaste. Calm, strengthen, protect: those are the three actions it is built around, in a single tube. The formula is patent-pending S3 Repair Technology™, UK application GB2604755.5. More than 20 UK dentists own S3, which is a fact about the company rather than evidence about the paste. Read more about S3.

References 34 sources

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UK government (gov.uk). Delivering better oral health: an evidence-based toolkit for prevention. Chapter 9: fluoride. https://www.gov.uk/government/publications/delivering-better-oral-health-an-evidence-based-toolkit-for-prevention/chapter-9-fluoride Accessed 2026-09-10. Page updated 10 September 2025.
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17
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21
Barbe AG. Medication-Induced Xerostomia and Hyposalivation in the Elderly: Culprits, Complications, and Management. Drugs & Aging, 35(10):877-885. 2018. doi:10.1007/s40266-018-0588-5 Design: review (narrative, practical); n: not applicable.
22
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23
Ritter AV, Bader JD, Leo MC, Preisser JS, Shugars DA, Vollmer WM, Amaechi BT, Holland JC. Tooth-surface-specific effects of xylitol: randomized trial results. Journal of Dental Research, 92(6):512-517. 2013. doi:10.1177/0022034513487211 Design: secondary analysis of a double-blind RCT (Xylitol for Adult Caries Trial, multicentre; ClinicalTrials.gov NCT00393055); n: 620 participants with at least one follow-up visit.
24
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25
Poulsen S, Errboe M, Lescay Mevil Y, Glenny AM. Potassium containing toothpastes for dentine hypersensitivity. Cochrane Database of Systematic Reviews. 2006. doi:10.1002/14651858.CD001476.pub2 Design: systematic review + meta-analysis (Cochrane); n: 6 RCTs in the meta-analysis; 390 participants in total and 108 patients in the three trials that carried a subjective assessment (both figures read from the full text on 2026-09-10, not in the abstract); 5 trials and 1 trial in the two tactile analyses, 3 trials in the subjective analysis.
26
Martins CC, Firmino RT, Riva JJ, Ge L, Carrasco-Labra A, Brignardello-Petersen R, Colunga-Lozano LE, Granville-Garcia AF, Costa FO, Yepes-Nuñez JJ, Zhang Y, Schünemann HJ. Desensitizing Toothpastes for Dentin Hypersensitivity: A Network Meta-analysis. Journal of Dental Research. 2020. doi:10.1177/0022034520903036 Design: systematic review + network meta-analysis; n: 125 RCTs, 12,541 patients; per-stimulus networks in the supplementary appendix: tactile 71 studies and 6,573 participants, air 85 studies and 7,940 participants, cold 16 studies and 1,093 participants; the potassium + hydroxyapatite node holds 2 RCTs and 140 patients on tactile and on air, and does not exist for cold; the potassium node holds 14 RCTs and 1,138 patients on tactile, 18 RCTs and 1,439 patients on air, and 4 RCTs and 231 patients on cold (appendix, added 2026-09-10 by ART-V212-20260910-1033).
27
Ekstrand KR, Poulsen JE, Hede B, Twetman S, Qvist V, Ellwood RP. A randomized clinical trial of the anti-caries efficacy of 5,000 compared to 1,450 ppm fluoridated toothpaste on root caries lesions in elderly disabled nursing home residents. Caries Research, 47(5):391-398. 2013. doi:10.1159/000348581 Design: RCT (parallel, six nursing homes; one calibrated examiner); n: 176 randomised, 125 completed.
28
Chan AKY, Tamrakar M, Jiang CM, Tsang YC, Leung KCM, Chu CH. Clinical evidence for professionally applied fluoride therapy to prevent and arrest dental caries in older adults: A systematic review. Journal of Dentistry, 125:104273. 2022. doi:10.1016/j.jdent.2022.104273 Design: systematic review + meta-analysis (PROSPERO CRD42022307025); n: 7 studies included (5 rated low risk of bias), from 527 identified.
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Antezack A, Ohanessian R, Sadowski C, Faure-Brac M, Brincat A, Etchecopar-Etchart D, Monnet-Corti V. Effectiveness of surgical root coverage on dentin hypersensitivity: A systematic review and meta-analysis. Journal of Clinical Periodontology. 2022. doi:10.1111/jcpe.13664 Design: systematic review + meta-analysis (of randomised controlled trials); n: 13 randomised controlled trials, 701 patients, 1,086 recessions.
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Lin PY, Cheng YW, Chu CY, Chien KL, Lin CP, Tu YK. In-office treatment for dentin hypersensitivity: a systematic review and network meta-analysis. Journal of Clinical Periodontology. 2013. doi:10.1111/jcpe.12011 Design: systematic review + network meta-analysis; n: 40 studies included, grouped into six treatment nodes.
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de Oliveira RP, Alencar CM, Silva FA, Magno MB, Maia LC, Silva CM. Effect of desensitizing agents on dentin hypersensitivity after non-surgical periodontal therapy: A systematic review and meta-analysis. Journal of Dentistry. 2020. doi:10.1016/j.jdent.2020.103498 Design: systematic review + meta-analysis (9 randomised clinical trials, five meta-analyses); n: 9 RCTs in the quantitative synthesis.
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Zhang J, Sardana D, Li KY, Leung KCM, Lo ECM. Topical Fluoride to Prevent Root Caries: Systematic Review with Network Meta-analysis. Journal of Dental Research, 99(5):506-513. 2020. doi:10.1177/0022034520906384 Design: systematic review + network meta-analysis (GRADE certainty assessed); n: 9 clinical trials, 4,030 participants.
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Srinivasan M, Schimmel M, Riesen M, Ilgner A, Wicht MJ, Warncke M, Ellwood RP, Nitschke I, Müller F, Noack MJ. High-fluoride toothpaste: a multicenter randomized controlled trial in adults. Community Dentistry and Oral Epidemiology. 2014. doi:10.1111/cdoe.12090 Design: RCT (multicentre, parallel, single-blind: examiner blinded; patients could tell the two pastes apart); n: 135 randomised, 130 analysed (64 test, 66 control) with 304 root caries lesions.
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National Institute for Health and Care Excellence. Oral health for adults in care homes (NG48): recommendations 1.2 and 1.3. https://www.nice.org.uk/guidance/ng48/chapter/Recommendations Accessed 2026-09-10.