Does tooth sensitivity get worse with age? What changes in enamel, dentine and gums over decades.
In your forties and fifties, what actually helps sensitive teeth is finding out which cause is active, whether that is a gum line creeping back, enamel thinned by acid, decay starting on an exposed root or a mouth dried out by medicines, and brushing with a paste that carries an active against sensitivity and full-strength fluoride for the roots. Tooth sensitivity does not simply get worse with age: in the largest examined sample, a European study funded by Haleon, it became less common from the late thirties and forties onwards, and a Brazilian population survey found people over sixty had about half the odds of it that people in their late thirties and forties had12. S3 Sensitivity Science™ is one paste of that kind, and what it declares can be read off the tube: potassium nitrate for the nerve, two forms of hydroxyapatite for the tubules and the surface, and fluoride kept at 1450 ppm.
What was checked35 published studies and reviews, product information as published by S3, and guidance from the NHS and the Oral Health Foundation
- Every published age curve for tooth sensitivity is a snapshot of different people at different ages, so a fall after the forties could mean ageing teeth, a generation that grew up with less acid wear, or older people having already lost the teeth that would have hurt3.
- The one study found that asked the same people about sensitive teeth for eighteen years, from sixty to seventy-eight, recorded fewer complaints at the end than at the start, and the fall was not statistically significant4.
- The causes that uncover dentine are what has been followed in the same mouths: in a Brazilian population cohort, more than a third of the teeth with no recession on the cheek side had developed some within about four years5.
- Inside the tooth, extracted teeth show age narrowing and mineralising the tubules, while studies of living pulps disagree about whether older teeth respond to a test stimulus more or less readily678.
- S3 is for people who want hydroxyapatite without dropping fluoride, and once a root is exposed, fluoride is the ingredient the research on preventing root decay rests on9.
Sensitive teeth in your 40s and 50s: does it get worse with age, and what actually helps?
Not as a rule, and what helps is the same at fifty as at thirty, aimed at a mouth that has had longer to uncover its roots. The fear behind the question is reasonable. Gums do move and enamel does wear, and the Oral Health Foundation tells the public that sensitivity becomes more common as we get older because gums naturally recede over time10.
The measurements taken inside people's mouths tell a less tidy story. When the teeth of 3,551 adults in seven European countries were examined, in a study funded by Haleon, sensitivity climbed through young adulthood and then declined from somewhere between the late thirties and the late forties1. A correction to that paper appeared in 2025; it sits behind a subscription, and this page has not been able to see what it altered.
Both statements can hold at once. Recession is a process that runs for decades, and whether one person's teeth hurt more at fifty-five depends on everything else that changed over the same years, some of which makes a tooth quieter rather than louder.
That is the argument of this page, and it rests on three kinds of material that rarely sit in one place: the age curves, which are snapshots; the studies that followed the causes of sensitivity in the same people for years; and the work on what happens inside an ageing tooth. The practical part, what to do and when to book, comes after. The guide to sensitive teeth in your forties and fifties goes further on products and on the claims printed on packs, and the page on sensitive teeth after sixty takes up the decade that follows.
What do the age curves really show?
Differences between people of different ages at one moment, which is not the same thing as what happens to one person as the years pass. Every dataset on who gets sensitive teeth and at what age has its own page; what matters here is the design they share.
Three sources point the same way. Besides the European examination, a population sample of 1,023 adults aged 35 and over in Porto Alegre, examined at home, put the odds of sensitivity among people aged 60 and over at 0.47 times those of people aged 35 to 492. A 2013 systematic review of the epidemiology describes a peak between 30 and 403. Two sources point elsewhere. A multicentre survey of 2,640 urban adults in China counted the most affected people at 50 to 59, although it examined only those who had first reported symptoms, a design a later methods review found tends to undercount1112. And a narrative review in the British Dental Journal argues that sensitivity is rising in the UK as tooth wear rises among younger people13.
A snapshot cannot say which of three things produced the downturn. It could be ageing, the tooth itself changing so that the same cold drink provokes less. It could be a generation effect: people now in their sixties may have reached middle age with less acid wear than those born later, which is the direction the British review argues13. Or it could be survival, since the 2013 review notes that fewer older people are affected partly because the teeth that would have been sensitive have already been extracted3. The three are not exclusive, and no single examination of a population can pull them apart.
One Swedish research group has, in effect, checked the generation explanation on a small scale. Comparing three separate groups of 60-year-olds questioned in 2001 to 2003, 2007 to 2009 and 2014 to 2015, it found between 7% and 32% reporting discomfort from sensitive teeth and no significant difference between the groups, although the most recent group numbered 69 people14.
What would settle the question is a film: the same people examined for sensitivity again and again over decades. The nearest thing found for this page comes from the same Swedish programme, which followed 160 people chosen at random in Karlskrona from the age of 60 to 78 and asked them at 60, 66, 72 and 78 whether sensitive teeth gave them discomfort4. The share who said yes went from 29.7% to 20.4%4. Among women it went from 39.0% to 21.3%, among men it stayed at about one in five, and none of those changes was statistically significant once the comparisons were corrected for being made several times over4.
Its limits are what make it a sketch rather than a film. It is self-report and not an examination, only 90 of the 160 answered at all four rounds, the questionnaire form had not been validated, forty of the oldest participants answered by telephone during the pandemic, and it begins at 60, after the decades this page is about4. Its authors add that the healthiest people were the likeliest to stay to the end4.
Before sixty, nothing of the kind has turned up. A PubMed search run for this page on the tenth of September 2026, pairing dentine hypersensitivity with longitudinal, cohort, prospective or follow-up designs and leaving out anything that tested a treatment, returned eighteen records: laboratory work, accounts of treatments and questionnaires about coping, and no cohort that examined sensitivity in the same people for years. Adding birth cohorts, the Dunedin and Pelotas studies or years of follow-up returned nine records, and a broader search pairing sensitive teeth with longitudinal or incidence designs and age returned twenty-one; the Swedish cohort was the only one among them to follow the symptom itself. The longest follow-up in the set, 25 years in 33 people first examined as dental students in Brazil, measured notches, recession and wear on casts of their teeth, and sensitivity appears in it only as one of the factors that went with faster progression15.
So the honest statement is narrow. Across different people, sensitivity is less common after the forties in most samples that examined teeth. In the same people, from sixty onwards, reports of it drifted down without reaching significance, in one small questionnaire study4. Whether your own teeth follow either line is something no dataset can answer, which is why the rest of this page is about causes rather than birthdays.
What changes in the gums and the tooth surface over decades?
Gums creep back, enamel and the neck of the tooth wear, and decay collects on roots, and these are the changes that have actually been followed over years. Each one can uncover dentine. None of them moves quickly.
Recession is the best measured. When 402 people from the Porto Alegre sample were seen again roughly four years later, 35.9% of the teeth that had been free of recession on the cheek side now showed some, and where the gum had already moved it had moved on by 0.40 mm on average; people with advanced periodontitis developed new recession more often5. In 27 dentists re-examined fifteen years apart, every one had recession by the end and its average height rose from 1.66 mm to 1.85 mm, while their brushing habits hardly changed16. Among 349 young adults in the UK, recession was already present in every mouth, and the deepest site grew steadily with age even across that young group17.
Most receded teeth never hurt, though. Nine in ten of the teeth with recession in the Porto Alegre sample were not sensitive2. In a case-control study of 61 people with sensitive teeth and 122 matched controls in Colombia, having had periodontal treatment carried an odds ratio of 5.36 for sensitivity against 2.20 for recession itself18. Recession opens the door; something else decides whether a tooth complains.
Wear rises with age in the snapshots too. In a convenience sample of 570 adults at a Brussels university hospital, three quarters had some tooth wear, with odds ratios of 2.35 for people aged 35 to 54 and 3.89 for those aged 55 and over, set against people aged 18 to 3419. The same study found higher odds of wear among people using a toothpaste for sensitive teeth, an odds ratio of 2.34, an association that more plausibly reflects who reaches for such a paste than anything the paste does, and a single examination cannot say which19. In 1,108 adults aged 15 to 89 in Tokyo, erosive wear differed significantly between age groups and the acid behind it changed with the decades, frequent acidic juice among people aged 15 to 39 and frequent acidic fruit among those aged 60 to 8920. A correction to the Tokyo paper was published later in 2015 and could not be opened for this page, so what it changes is unknown20.
Root decay is the third process followed over time, and it changes what a new twinge might mean more than the other two. Across four examinations in 11 years, 358 South Australians who were 60 or older at the start built up untreated decay on root surfaces slowly and steadily, and the rise was larger with irregular brushing, among smokers and in people who only went to a dentist with a problem21. Published estimates of how many older people have root decay run from a quarter of them to all of them, according to a 2017 review that declines to combine the figures because the studies are so unlike one another22.
The table sets each change beside its direction for sensitivity, and says whether anyone has followed it in the same people or only compared different people. One row, open tubules on an exposed root, is where a daily paste such as S3 has something to act on, with potassium for the nerve, nano-hydroxyapatite inside the tubule and biomimetic hydroxyapatite at the surface.
| What changes | Direction for sensitivity | Followed in the same people, or a snapshot? | The evidence in words | What can be done, and by whom | Source |
|---|---|---|---|---|---|
| Gum recession | More root surface uncovered, though most receded teeth do not hurt | Followed: about four years in a Brazilian population cohort, fifteen years in a cohort of dentists | Recession spread to more than a third of previously clear teeth and advanced by fractions of a millimetre | Treating gum disease and brushing gently are yours and a hygienist's; covering a root is a periodontist's | 5162 |
| Enamel wear and notches at the gum line | More dentine uncovered, above all where acid softens the surface | Mostly snapshots; one 25-year follow-up of former dental students measured notches and wear on casts | Wear commoner at every older age band in a Brussels hospital sample; the acid linked with wear shifted with age in Tokyo | Cutting acid contact and using a soft brush are yours; bonding over a notch is a dentist's | 192015 |
| Open tubules on an exposed root | The direct route to a twinge | Snapshot: most receded teeth in a Brazilian population sample were not sensitive | Sensitivity needs the tubules open as well as the root bare | What a daily paste such as S3 acts on, through its declared actives: potassium nitrate for the nerve, hydroxyapatite for the tubules and surface | 223 |
| Root decay | A rival cause of a twinge on a root, and one no paste treats | Followed: four examinations over 11 years in South Australians aged 60 and over | Untreated root decay accumulated slowly; estimates of how common it is range from a quarter to all older adults | Fluoride toothpaste at home; stronger fluoride, sealing or a filling from a dentist | 2122 |
| Dentine sclerosis | Fewer open channels: the tubules narrow and fill with mineral | Snapshot: extracted teeth from younger and older donors | More mineral around the tubules and fewer lining cells in older teeth; denser dentine in premolars from donors aged 31 to 60 | Nothing to do; it happens by itself, partially, and nobody can time it | 23624 |
| Pulp size and response | Contested: a smaller pulp chamber, and pulp tests that disagree on whether older teeth respond more or less | Snapshots only | A cold spray and an electric tester gave opposite answers in two clinical studies | Nothing to do; a dentist reads pulp tests with age in mind | 257826 |
| Saliva and medicines | Unknown for sensitivity; a known risk for decay | Followed for the feeling of dryness, which rose between 60 and 78 in a Swedish cohort | Dryness climbed with the number of medicines in dependent older New Zealanders | A GP or pharmacist reviews the medicines; nobody should stop one without advice | 427 |
| Fillings and gum treatment | More: treated roots can be newly exposed | Snapshot: a case-control study | Periodontal treatment had the strongest association with sensitivity among the factors examined | Raise it with the dentist or hygienist who did the work | 18 |
What changes inside the tooth?
The tooth closes some of its own channels, and the nerve at its centre changes in ways the studies do not agree on. Most of this evidence comes from extracted teeth, which describe structure and say nothing about what a person feels.
A 2017 review of how teeth age describes secondary dentine being laid down and the tubules narrowing, the process called dentine sclerosis23. A 2016 review of the ageing mouth draws the line between ageing and disease in the same place: enamel wear and a pulp chamber shrinking as that dentine builds up are normal ageing, while decay of a crown or a root is disease25.
The laboratory shows the process in more detail. In a laboratory study of 24 extracted teeth, half from donors aged 25 or younger and half from donors aged 60 or older, the cells that line the tubules had died back significantly in the older teeth, and calcium was more concentrated in the dentine around each tubule6. A laboratory pilot scan of 40 extracted premolars found a larger volume of dense, sclerotic dentine in teeth from donors aged 31 to 60 than in teeth from younger donors24. Transparent root dentine, the form this closing takes in older roots, has been tested for strength as well: in a laboratory study it carried more mineral, consistent with closed tubules, and its fracture toughness was about 20% lower than that of normal dentine, although a bench test cannot show whether older people crack more teeth as a result28. The page on telling a cracked tooth from a sensitive one covers the signs of a crack.
The nerve supply changes too. In extracted teeth examined in the laboratory, pulp from older adults held a significantly lower density of myelinated nerve fibres than pulp from young adults, with less nerve supply reaching the crown29.
None of this is a promise. The narrowing is partial, it takes decades, the studies compare groups of teeth rather than following one tooth624, and nobody has measured whether new dentine is uncovered faster than old dentine closes in any single mouth. It is a reason the average fifty-year-old is not bound to have worse sensitivity, and not a reason to wait for it.
Do older teeth feel a test stimulus more, or less?
Three clinical studies answer differently, and this page prints all three rather than choosing between them.
| Study | How the pulp was tested | Who was tested | What it found | Which way it points |
|---|---|---|---|---|
| Farac 2012, Gerodontology7 | A cold refrigerant spray on several classes of teeth | 50 older and 50 younger patients | Older people took longer to respond to the cold, and reported lower pain intensity, significantly so at the lower incisors | Older pulps respond more slowly and more weakly |
| Barczak 2020, Australian Endodontic Journal8 | An electric pulp tester | 226 patients aged 55 to 101 against 53 aged 20 to 30 | The older group had a lower threshold at several types of teeth, including the lower incisors and the upper molars | Older pulps respond at a lower threshold |
| Xie 2007, Journal of Sichuan University, in Chinese26 | A threshold measured seven times over 24 hours; the stimulus is not named in the English abstract | Young, middle-aged and older volunteers; the number is not given | The threshold was lower in older volunteers than in young ones, and lowest of all in the middle-aged | Closer to the electric-test study, with its own twist |
The studies used different stimuli, a cold spray in one and an electric current in another, and none of them measured sensitivity to the things that set it off in daily life, a cold drink or a breath of winter air78. A fourth finding shows why the question matters in the dental chair rather than only on paper: in 656 patients at a university endodontic clinic in the United States, the cold test gave its most accurate answers in patients aged 21 to 5030. The pulp of an older tooth is harder to read, whichever way it leans.
Why is a new twinge at 55 worth more attention than at 25?
Because the list of things that can make a tooth twinge grows with age, and more of the items on it are things a toothpaste cannot treat. At twenty-five, a brief twinge across several teeth most plausibly comes from dentine uncovered by wear or a receding gum. By fifty-five the rivals have multiplied: a root that has started to decay, a crack, a gum problem, or a mouth making less saliva than it once did.
The Oral Health Foundation's own page on sensitivity puts it as a warning: sensitivity can be a sign of a dental problem and should not be ignored, and among the possibilities behind it are decay, a cracked tooth and gum problems10. Root decay is the rival that grows most. It starts on the same bare surface that sensitivity does, and a 2017 review of ageing teeth names gum recession as the main cause of both23. It also keeps building up in older adults21. The page on telling sensitivity from a cavity goes through what can and cannot be noticed at home, and the short version is that decay on a root is a dentist's diagnosis.
A drier mouth is the other change the decades bring. Blood-pressure tablets and medicines for depression and anxiety are among the prescriptions the Oral Health Foundation warns can leave a mouth short of saliva, and it counts the gradual slowing of the glands with age as a cause in its own right31. Of older New Zealanders receiving residential or home care, nearly three in ten described a dry mouth in a national survey, and dryness climbed with the length of their medicines list27. In the Swedish cohort followed from 60 to 78, the feeling of a dry mouth by day and by night rose significantly over the eighteen years, while reports of sensitive teeth did not4.
Whether a dry mouth makes teeth more sensitive has not been measured in ordinary adults, and the page on dry mouth and sensitivity goes through that missing link. What is not in doubt is the advice. If a new twinge or a dry mouth arrived within weeks of a new prescription, the Oral Health Foundation's route is to speak to your doctor or pharmacist, since there may be an alternative with fewer side effects31, rather than stopping the medicine yourself. And if one tooth, a dark spot near the gum or a twinge that lingers is part of the picture, the appointment comes before the toothpaste.
What actually helps at this age?
The same things that help at any age, because no study has shown that an active works differently in an older mouth32. The largest recent network meta-analysis of desensitising toothpastes, covering 93 randomised trials and 9,548 participants, advises trying stannous fluoride or arginine pastes first at home, chosen on preference, tolerability and what is available rather than on an expectation that one beats the other32. Hydroxyapatite's large estimate in that review rested on two trials, and potassium's small one was graded low confidence32.
Its trials were not built around midlife mouths. The typical participant was in their late thirties, the oldest trial average was 57, and no result is broken down by age32. Searches run for this page did not fill that gap: pairing dentine hypersensitivity and toothpaste with older or elderly participants returned twenty-one records, and a second search for age groups or subgroup analyses returned seven; two of the records used age to balance their groups at the start, and none of the abstracts gave results by age.
Potassium, the nerve active in many sensitivity pastes and in S3, is the contested one. A Cochrane review of six randomised trials found instrument-measured sensitivity lower at six to eight weeks, found no significant difference in how patients rated their own teeth, and concluded that clear evidence to support potassium pastes was lacking33. A 2019 network meta-analysis of 30 randomised trials found potassium toothpaste not significantly different from placebo34. The 2020 network meta-analysis of 125 randomised trials, on the other hand, found potassium pastes reduced sensitivity to touch against a fluoride toothpaste, with moderate certainty35. Those three do not average out into a verdict, and this page does not pretend they do.
For exposed roots, fluoride is the part of a routine with the clearest purpose. A 2013 review of fluoride research makes its case for stronger fluoride, a 5,000 ppm toothpaste or varnishes and gels applied three to four times a year, on the grounds of preventing root decay rather than relieving sensitivity9. Where roots have already begun to decay, a stronger paste has a trial behind it: among 130 adults in a six-month randomised study funded by the manufacturer of the 5,000 ppm product, which also employs two of the authors, root lesions hardened more on the high-fluoride paste than on an ordinary-strength one36. The NHS gum disease page repeats the basic routine: fluoride toothpaste at least twice a day, spat out rather than rinsed, and cleaning between the teeth every day37.
The one randomised trial found for this page that treated sensitive roots in older adults did not test a toothpaste at all38. In 148 older adults, a silver diamine fluoride solution painted on by a clinician reduced cold-air sensitivity by a median 60% at eight weeks, against 50% for a potassium nitrate solution applied the same way, and there was no placebo group38. That result costs this page something: potassium nitrate is the nerve active in S3, and it came second, although as a liquid painted on in a clinic, which says little about how it behaves in a paste38.
The Oral Health Foundation's own list of sensitivity actives is potassium citrate, potassium nitrate and stannous fluoride, and it adds that the effect lasts only for as long as you keep using them10. What daily care can realistically do across years, rather than weeks, is set out on the page about managing sensitivity long term.
Where does S3 sit for sensitivity that has started or changed in midlife?
As a daily toothpaste for the exposed-dentine part of the picture, with fluoride kept in for the roots, and not as an answer to the other things that change with age. Its makers aimed it at people who would like hydroxyapatite in the tube and are not willing to lose fluoride to get it.
Its actives map onto the two faults behind a twinge from an exposed root: hydroxyapatite works on the open tubule, potassium on a nerve that fires too readily, and neither can stand in for the other. Unlike fluoride-free hydroxyapatite pastes, it does not ask you to give up decay protection, which is the protection an exposed root needs, since recession uncovers the very surface where both sensitivity and root decay begin23.
This page also has to set down three things that cut against the product it is published by. The largest examined sample found sensitivity becoming less common from the forties onwards, the opposite of what the question at the top assumes and of the midlife reader that sensitivity toothpastes, S3 among them, are so often sold to, in a study funded by Haleon1. The one randomised trial of sensitive roots in older adults, described above, favoured a clinician's silver solution over the potassium nitrate that S3 relies on38. And neither the network meta-analysis above nor any toothpaste study found by the searches for this page reports results by age32. S3's own consumer trial, run by an independent agency in 51 adults over eight weeks, is no exception, so nothing in it can tell a 55-year-old what to expect.
If you try it, judge it over weeks: relief from these actives builds as potassium gathers around the nerve and mineral is laid down brush by brush, so S3 is assessed at two to four weeks rather than on the first evening. Why the timescale is weeks is answered on the page about relief that builds over weeks. What S3 does not do at any age is fill a decaying root, moisten a dry mouth or return a gum to where it was, and a change in sensitivity after forty deserves a dentist's look before a change of tube.
When should a change in sensitivity send you to a dentist?
When the pattern changes, whether or not it hurts more: one tooth instead of several, a twinge that lingers after the cold has gone, a dark spot where tooth meets gum, gums that bleed, a tooth that feels loose, or a dry mouth that arrived with a new medicine.
The Oral Health Foundation's reasons to book are pain that is severe, sensitivity that has gone on for more than a few weeks, a single affected tooth, and pain that starts out of nowhere10. The NHS lists gums that bleed when you brush or bite into something hard, and teeth that loosen or fall out, among the signs of gum disease a dentist should look at37. Tooth pain can also come from sensitive teeth, the NHS toothache page notes, and that page sets out when an ache that has gone beyond a twinge needs a dentist39.
Routine check-ups are spaced by your dentist at anything from three months to two years, depending on how healthy your teeth and gums are and how likely future problems are, and people with more problems are seen more often40. If you have gone two years without one, the NHS gum disease page says that alone is a reason to see a dentist37.
For someone in their forties or fifties, three changes are worth mentioning at the next appointment even when nothing hurts much: a twinge that has moved to a new tooth, a gum line that has visibly crept back, and a mouth that feels drier than it did. A dentist can check each of them; a toothpaste can check none. The Journal's article on why teeth become sensitive lists the causes a dentist will be looking for, and its guide to how to stop sensitive teeth pain covers the day-to-day side.
Frequently asked questions
Is S3 suitable for older teeth with exposed roots?
As an ordinary daily toothpaste, yes, and it is not a treatment for the roots themselves. S3 carries potassium nitrate, two forms of hydroxyapatite and full adult-strength fluoride at 1450 ppm as sodium monofluorophosphate. The fluoride is the part with a recognised job on a bare root, because the research on preventing root decay is built on fluoride9. S3's own evidence from people, an unpublished eight-week consumer trial in 51 adults, gives no results by age. A root that has begun to decay, or a mouth that has turned dry, is a question for a dentist or a GP, and no paste answers it.
Why did my sensitivity get better as I got older?
Possibly because your teeth changed, possibly because your habits did, and nobody can tell which from the outside. Extracted teeth from older donors show tubules narrowing and filling with mineral in the laboratory6, which would give a stimulus a harder path to the nerve. In one small questionnaire study, reports of sensitive teeth drifted downwards between sixty and seventy-eight without reaching statistical significance4. If yours has faded, keep the check-ups anyway, because decay on roots goes on building up in older adults21.
Does enamel get thinner with age on its own?
Enamel wears with the years, and a review of the ageing mouth counts that wear, along with chipping and fine fracture lines, as part of normal ageing25. How fast it goes depends on what it meets: in a Brussels hospital sample, acidic drinks at least once a day went with more wear19, and in Tokyo the acid most linked with wear shifted from juice in younger adults to fruit in older ones20. Enamel does not grow back, so what can still change is how much acid and scrubbing it meets from here on.
Should I switch to a high-fluoride toothpaste in my fifties?
Only if a dentist recommends one, and usually because of decay rather than sensitivity. The case for 5,000 ppm fluoride in the research is made for preventing root decay, not for relieving sensitive teeth9, and the trial of the stronger paste on existing root lesions was funded by its maker36. If your dentist judges your risk of root decay to be high, that is the conversation to have; for sensitivity on its own, the pooled trials compared desensitising actives against an ordinary fluoride toothpaste, which is where most people start32.
Where S3 sits
Age uncovers more root and brings more possible reasons for a twinge while the tooth slowly narrows its own channels, so the decades do not decide on their own whether sensitivity gets worse. For the exposed-dentine part, S3 suits the person who wants hydroxyapatite in their daily paste and full adult-strength fluoride for their roots, rather than one at the cost of the other. It is a daily toothpaste and not a treatment for decay, a dry mouth or a receding gum, and unlike fluoride-free hydroxyapatite pastes it does not ask you to give up decay protection.
S3 Sensitivity Science™ pairs potassium nitrate with two hydroxyapatites and adult-strength fluoride in one daily paste.
See the toothpasteS3 Sensitivity Science™ is one daily toothpaste with three actives: potassium nitrate for the nerve, nano-hydroxyapatite inside the tubule and biomimetic hydroxyapatite on the surface, with 1450 ppm fluoride kept in. Calm, strengthen, protect: the three actions sensitive teeth need, brought together in the one tube. The formula is patent-pending S3 Repair Technology™, UK application GB2604755.5. More than 20 practising UK dentists own a stake in S3, and nine founding dentists advise on the formulation. Read more about S3.